Misako (みさこ) is a fictional character in Kunio-kun series. She first debuted in Nekketsu Kōkō Dodgeball Bu: Soccer Hen and she is the manager of the school's Soccer Club. She is also a playable character and Kunio's partner in Kunio-tachi no Banka, and appeared shortly after in Kunio No Oden. She is also in Shin Nekketsu Koha Kunio Kun Special, present in the game's Story Mode. A trailer  released seemed to indicate that she would be playable in Battle Royal mode, as she was pictured in the part of the video that discusses that mode, but she is not. In 熱血硬派くにおくんSP 乱闘協奏曲 (Auto-Translation: Renegade country-Kun SP Brawl Concerto), she again plays a role in the story mode along with her Banka partner, Kyouko, but neither is playable.
Misako was one of the main characters in NOTTV's 2013 television adaptation of the Kunio series.
She finally became a playable character again in the second DLC pack for PS3version of Downtown Nekketsu Koushin Kyoshu Daiundokai, as a member of Misuzu's team; alongside Kyouko and girls from the original Nekketsu Kouha Kunio Kun. She retains her spin-kick and somersault attack from Tachi No Banka, and also starts matches with a sword.
Misako, like many characters in the series, appears differently depending on the game. Most art, as well as her sprite appearance in Kunio No Oden and model in River City Soccer Hooligans, depict her as having medium-length blue hair, worn naturally and with a bow, but the 8-Bit sprites depict her as having black hair worn in a ponytail, with no noticeable bow. In Kunio Tachi No Banka and Daiundokai 3DS, she has blue hair but cut shorter and without a bow.
Misako's combat-style is largely based around kicking, perhaps in relation to her interest in soccer. Three of her four special moves in Kunio Tachi No Banka utilize her lower-body; a flying knee, spin-kick, and mule kick; the remaining special is an aerial somersault. In one memorable scene, Kunio and Riki delegate to Misako the responsibility of torturing a boss to confession by kicking him in the groin.